A bone marrow transplant, also known as a stem cell transplant, is a medical procedure that replaces a patient's damaged or diseased bone marrow with healthy stem cells. Bone marrow is the spongy tissue inside bones where blood cells are produced. Stem cells are immature cells that can develop into any type of blood cell. 

Bone marrow transplants are used to treat a variety of conditions, including leukemia, lymphoma, multiple myeloma, sickle cell anemia, and thalassemia. Stem cell transplant works by first destroying the patient's diseased bone marrow with high-dose chemotherapy and/or radiation therapy. Once the diseased bone marrow is destroyed, healthy stem cells are transplanted into the patient's body, where they can begin to produce new blood cells.  

Stem cell transplant is a complex procedure that requires specialized expertise and infrastructure. At Sterling Hospitals Gandhidham , we have a dedicated stem cell transplant team that includes hematologists/oncologists, transplant nurses, and other healthcare professionals who work together to provide comprehensive care for our patients.  

While stem cell transplant can be an effective treatment option for certain blood cancers, it can also cause side effects, such as infections, bleeding, and graft-versus-host disease (GVHD).  

Our team is experienced in managing these side effects and providing supportive care to ensure the best possible outcome for our patients.  

If you or a loved one has been diagnosed with a blood cancer, contact us at Sterling Hospitals Gandhidham  to learn more about our stem cell transplant services and how we can help in your cancer journey  

• What is a bone marrow transplant?  

A blood or marrow transplant (BMT) is a treatment option for people with a blood cancer, such as leukemia or lymphoma, or a blood disorder, like sickle cell disease.  

• How does a blood or marrow transplant (BMT) work?  

A blood or marrow transplant (BMT) replaces unhealthy blood-forming cells with healthy ones. Blood-forming cells (blood stem cells) are immature cells that grow into red blood cells, white blood cells and platelets. They’re found in the soft tissue inside your bones, called bone marrow. When they’re mature, they leave the marrow and enter the bloodstream.  

Before transplant, you get chemotherapy (chemo) and sometimes radiation to destroy the diseased cells and marrow. Then, the healthy cells are given to you.  

BMT is not surgery. The new cells go into your bloodstream through an intravenous (IV) catheter or tube. It’s just like getting blood or medicine through an IV. From there, the cells find their way into your marrow.. It can take months or years to recover from BMT. Learn more about what to expect before, during and after BMT.  

• Where do the healthy cells come from?  

The healthy blood-forming cells used in a transplant can come from three sources:   

• Bone marrow, peripheral blood stem cells (PBSC), and cord blood. Bone marrow is the spongy tissue inside of bones where blood-forming cells are produced.  

• PBSCs are blood-forming cells that can be collected from the circulating blood.   

• Cord blood refers to the blood collected from the umbilical cord and placenta after a baby is born.   

All three sources can be used in bone marrow transplantation depending on the patient's specific needs and medical condition.  

• What are the different types of BMT?  

There are two main types of bone marrow transplants (BMT): autologous and allogeneic. An autologous transplant involves using the patient's own blood-forming cells, while an allogeneic transplant uses blood-forming cells donated by someone else.  

Within allogeneic transplants, there are several subtypes:  

• Matched related donor (MRD): the donor is a close family member (such as a sibling) who has a closely matched human leukocyte antigen (HLA) type.  

• Matched unrelated donor (MUD): the donor is not related to the patient but has a closely matched HLA type. The donor is typically found through a registry.  

• Haploidentical donor: the donor is a half-match, usually a parent or child. This type of transplant is also called a haplo transplant.  

Other terms you may hear include:  

• Allo transplant: short for allogeneic transplant  

• Auto transplant: short for autologous transplant  

• SCT: short for stem cell transplant  

• HCT: short for hematopoietic cell transplant.  

• Which type of transplant is best for me?  

Determining which type of transplant is best for an individual patient depends on several factors, including the type of disease or disorder being treated, the stage and severity of the disease, the patient's age and overall health, and the availability of suitable donors.  

The decision regarding the type of transplant to be performed is made by a team of medical experts, including a hematologist, an oncologist, a transplant surgeon, and other healthcare professionals. They will evaluate the patient's medical history, conduct a physical examination, and perform various tests to determine the best treatment plan for the patient.  

If you are considering a bone marrow transplant, it is recommended that you consult with a hematologist or oncologist Sterling Hospitals Gandhidham , where a team of experienced healthcare professionals can provide you with comprehensive evaluation, guidance, and treatment options based on your individual needs and circumstances.  

• What diseases can BMT treat?  

• A bone marrow transplant (BMT) can be used to treat various types of cancers and non-cancerous blood disorders. Some of the cancers that can be treated with a BMT include:  

• Leukemia  

• Lymphoma  

• Multiple myeloma  

• Neuroblastoma  

• Hodgkin's disease  

• Non-Hodgkin's lymphoma  

• Myelodysplastic syndrome (MDS)  

• Myeloproliferative neoplasms (MPN)  

Non-cancerous blood disorders that can be treated with a BMT include:  

• Sickle cell anemia  

• Aplastic anemia  

• Thalassemia  

• Fanconi anemia  

• Paroxysmal nocturnal hemoglobinuria (PNH)  

It is important to note that a bone marrow transplant is not the first treatment option for all of these diseases and disorders. The suitability of a BMT as a treatment option depends on various factors, including the stage and severity of the disease, the patient's age and overall health, and the availability of a suitable donor. The decision to undergo a BMT should be made in consultation with a medical professional.  

Common Procedures   

• Paediatric BMT Program   

• Autologous Bone marrow/ Stem cell Transplant  

• Allogenic Bone Marrow/ Stem cell transplant  

• Haploidentical bone marrow transplant  

At Sterling Hospitals Gandhidham , we take pride in having a dedicated and experienced bone marrow transplant team that provides comprehensive care for our patients. Our team includes specialized team of Pediatric hematologists/Oncologists, Pediatric intensivists who provide exceptional care for our young patients. Our Pediatric team is committed to providing compassionate and family-centered care for children undergoing bone marrow transplant, ensuring that they receive the support and attention they need throughout the entire treatment process.  

Pediatric bone marrow transplant (BMT) is a complex medical procedure that involves the replacement of a child's diseased or damaged bone marrow with healthy stem cells. The new stem cells can help produce new blood cells and treat various conditions such as leukemia, sickle cell anemia, and genetic disorders.  

Types of Paediatric BMT  

There are two types of BMT for children:   

Autologous Transplantation And Allogeneic Transplantation.   

Autologous transplantation involves using the child's own stem cells, while allogeneic transplantation uses stem cells from a compatible donor. The type of transplantation used depends on the child's specific condition, age, and other factors, and will be determined by the child's healthcare team.  

Indications :  

Pediatric BMT is indicated for various conditions such as   

• Leukaemia  

• Lymphoma  

• Aplastic anemia  

• Sickle cell disease  

• Other genetic disorders that affect the bone marrow's ability to produce healthy blood cells.   

However, not all children with these conditions are eligible for BMT, and the decision to undergo BMT is based on various factors such as the child's age, overall health, and the stage of the disease.  

Side Effects:  

Pediatric BMT carries significant risks and potential side effects. During the treatment, the child may experience side effects such as nausea, vomiting, hair loss, fatigue, and decreased appetite. Long-term risks include infection, graft-versus-host disease, organ damage, and infertility. The healthcare team will carefully monitor the child's condition and manage any side effects or complications that may arise.  

Preparing Your Child for BMT:  

Preparing your child for BMT is a crucial part of the process. It involves various steps, including a medical evaluation, counselling, and education about the procedure, hospitalization, and recovery. Parents can help their child by creating a positive and supportive environment, addressing their fears and concerns, and ensuring their emotional and mental well-being.  

Life After BMT  

Life after bone marrow transplant (BMT) for children involves a long-term follow-up and management plan. The child may need to continue taking medications, undergo regular medical check-ups, and make lifestyle modifications such as avoiding exposure to infections and maintaining a healthy diet and exercise routine. The child's healthcare team will work closely with the family to provide ongoing support and guidance throughout the post-transplant period. 

At Sterling Hospitals Gandhidham , we have a dedicated pediatric bone marrow transplant team that works closely with parents and caregivers to develop a customized treatment plan that meets the unique needs of each child. We understand that undergoing BMT can be a challenging experience for children and their families, and we are dedicated to providing the highest level of care and support to ensure a successful outcome. 

With our experienced and dedicated team, we strive to provide the best possible outcomes for every patient, including our young patients. 

 Autologous Bone Marrow/ Stem Cell Transplant  

An autologous stem cell transplant, also known as an autologous bone marrow transplant, is a medical procedure that involves using a patient's own healthy blood stem cells to replace their diseased or damaged bone marrow. This type of transplant is recommended for people who require high doses of chemotherapy and radiation therapy to treat their disease, which can damage their bone marrow.  

The autologous stem cell transplant process starts with the administration of medications to the patient to stimulate the production of stem cells in their blood. The stem cells are then collected through a process called apheresis, where a machine filters them from the blood and returns the rest of the blood to the patient. The collected stem cells are then preserved and stored for later use.  

The patient then undergoes high doses of chemotherapy or radiation therapy to destroy their cancer cells. Once this treatment is complete, the patient receives an infusion of their own preserved stem cells, which will travel to their bone marrow and begin creating new blood cells.  

After the transplant, the patient is closely monitored by their medical team for any side effects and to ensure the success of the procedure. An autologous stem cell transplant is commonly used to treat conditions such as Hodgkin's lymphoma, myeloma, non-Hodgkin's lymphoma, and plasma cell disorders.  

At Sterling Hospitals Gandhidham , our medical professionals are skilled in performing autologous stem cell transplants to help patients with these conditions, using state-of-the-art technology and personalized care.  

Allogenic Bone Marrow/ Stem cell transplant  

An allogeneic transplant is a type of stem cell transplant that involves using stem cells from a donor to replace the diseased or damaged bone marrow of a patient. The donor is typically a close relative or someone with a closely matched tissue type. The goal of an allogeneic transplant is to give the patient new, healthy stem cells that can create new blood cells and rebuild their immune system.  

Allogeneic transplants are typically used to treat conditions such as leukemia, lymphoma, and other blood disorders. They may also be used to treat other types of cancer, such as multiple myeloma, or to replace a patient's bone marrow after high-dose chemotherapy or radiation therapy. In some cases, allogeneic transplants may be used as part of a clinical trial for the treatment of other conditions.  

The allogeneic transplant process involves several steps. First, the patient undergoes a conditioning regimen of high-dose chemotherapy and/or radiation therapy to destroy their diseased bone marrow and make room for the donor's stem cells. The patient is then given the donor's stem cells through an IV infusion.  

After the transplant, the patient is closely monitored for any complications, such as infections, graft-versus-host disease (GVHD), or other side effects. GVHD occurs when the donor's immune system attacks the patient's body, and can cause skin rashes, digestive issues, and other problems.  

At Sterling Hospitals Gandhidham , we have a team of experienced medical professionals who specialize in performing allogeneic transplants. We use the latest technology and techniques to ensure the best possible outcome for our patients. Our transplant team includes hematologists, oncologists, and other specialists who work together to provide comprehensive care throughout the transplant process.  

We also offer a range of support services to help patients and their families during this challenging time. Our team includes social workers, nutritionists, and other professionals who can provide guidance and support throughout the transplant process.  

If you or a loved one has been diagnosed with a condition that may require an allogeneic transplant, our team at Sterling Hospitals Gandhidham  is here to help. We are committed to providing compassionate, personalized care to each of our patients, and to working together to achieve the best possible outcomes.  

Haploidentical bone marrow transplant  

Haploidentical bone marrow transplant is a type of stem cell transplant that involves using stem cells from a donor who is a half-match for the recipient. In a haploidentical transplant, the donor is typically a family member, such as a parent, child, or sibling, who shares only half of the recipient's human leukocyte antigen (HLA) tissue type.  

HLA markers are proteins on the surface of cells that are used to identify the body's own cells and tissues from foreign cells and tissues. The closer the HLA match between the donor and recipient, the lower the risk of graft-versus-host disease (GVHD), a common complication of allogeneic stem cell transplants in which the donor's immune cells attack the recipient's body.  

In a haploidentical transplant, the donor's stem cells are collected and then treated to remove T-cells, which are the immune cells that can cause GVHD. This process is called T-cell depletion, and it reduces the risk of GVHD in the recipient.  

After T-cell depletion, the donor's stem cells are infused into the recipient's bloodstream, where they travel to the bone marrow and begin to create new blood cells. The recipient will receive high-dose chemotherapy or radiation therapy prior to the transplant to destroy any remaining cancer cells and make room for the donor's stem cells.  

At Sterling Hospitals , we offer haploidentical bone marrow transplants as a treatment option for patients with blood disorders, such as leukemia, lymphoma, and other conditions. Our transplant team includes experienced hematologists, oncologists, and other specialists who work together to provide comprehensive care throughout the transplant process.  

We use the latest technology and techniques to ensure the best possible outcomes for our patients, and we offer a range of support services to help patients and their families during this challenging time. Our team includes social workers, nutritionists, and other professionals who can provide guidance and support throughout the transplant process.  

If you or a loved one has been diagnosed with a blood disorder that may require a haploidentical bone marrow transplant, our team at Sterling Hospitals Gandhidham  is here to help. We are committed to providing compassionate, personalized care to each of our patients, and to working together to achieve the best possible outcomes.